Express Scripts Reports a 42 Percent Increase in Full-Year 2007 Adjusted Earnings Per Share

Fourth Quarter Adjusted Earnings Per Share Up 33 Percent




            2008 Earnings Per Share Guidance Increased

ST. LOUIS, Feb. 21, 2008 (PRIME NEWSWIRE) -- Express Scripts, Inc. (Nasdaq:ESRX) announced fourth quarter net income of $138.5 million, or $0.54 per diluted share. Excluding non recurring items in both years, earnings per diluted share was a record $0.68, a 33 percent increase over $0.51 per diluted share last year. All per share amounts have been adjusted to reflect the Company's 2-for-1 stock split, which was effective June 22, 2007. Cash flow from operations for the fourth quarter was a record $329.0 million compared to $306.0 million for the same period last year.

For the year, the Company reported net income of $567.8 million, or $2.15 per diluted share. Excluding non-recurring items in both years, earnings per diluted share was a record $2.35, a 42 percent increase over $1.65 per diluted share last year. The Company reported record cash flow from operations of $827.3 million compared to $658.6 million in 2006.

"We enjoyed another successful year of providing innovative solutions that helped our clients better manage their drug trend," stated George Paz, president, chief executive officer and chairman. "Our outstanding results demonstrate the power of aligning interests, which means that as we save our clients and their patients money, our performance improves. As we move to the next level of alignment, enabling better health and value one consumer at a time, we will be able to deliver increased savings through lower-cost drugs and channels, better outcomes through improved therapy adherence, and a strong position around emerging specialty opportunities.

"As we look to 2008 and beyond, the fundamentals of our business remain strong. We believe we are well-positioned in the marketplace and have built a platform for delivering superior value to our clients and superior growth for our stockholders."

Last quarter, the Company announced that it would review the strategic fit of the infusion business in its product portfolio. As a result of this review, the Company is in the process of selling this business unit, which has been reclassified to discontinued operations for all current and prior periods. Accordingly, the results for the quarter and year are segregated between continuing and discontinued operations.

Fourth Quarter Review - Continuing Operations

Gross profit for the fourth quarter increased 13 percent to $465.0 million from $409.7 million last year. The increase reflects lower retail and home delivery drug purchasing costs and higher generic utilization. Generic utilization reached a record 63.7 percent compared to 59.7 percent last year. These increases were partially offset by a non-recurring inventory charge discussed below. Gross profit per adjusted claim was a record $3.60, a 14 percent increase over $3.15 for the same quarter last year.

The following table provides a reconciliation of reported operating income to adjusted operating income for the PBM and Specialty and Ancillary Services ("SAAS") segments:



                                             Calculation of Adjusted
                                                Operating Income
                                                3 Months Ended
                                               December 31, 2007

                                           PBM      SAAS  Consolidated
                                         -----------------------------

 Operating income as reported             $280.8   $ (1.2)     $279.6

 Non-recurring legal expenses -
  $13 million this quarter vs.
  $7 million in a normal quarter             6.0       --         6.0
 Non-recurring inventory charges in
  specialty distribution, the majority
  pertained to a write-off of flu-related
  inventory due to the mild flu season        --      9.1         9.1
 Non-recurring bad debt charge in
  the SAAS segment                            --      3.0         3.0
                                         -----------------------------
 Adjusted operating income                $286.8   $ 10.9      $297.7
                                         =============================

Adjusted operating income for the fourth quarter increased 23 percent to $297.7 million from $242.4 million last year. Adjusted PBM operating income excludes legal expenses of $6.0 million, which are higher than a normal quarter due to developments in some open cases. Adjusted operating income for the SAAS segment, which excludes the non-recurring charges identified in the table above, was impacted by the milder than normal flu season, and severance and other costs incurred to integrate the operations and administrative functions of the SAAS segment within the PBM segment. The combination of the PBM and specialty offerings contributed to strong adjusted operating income for the PBM segment, which increased 29 percent to $286.8 million from $222.2 million last year.

Higher generic utilization and lower retail and home delivery drug purchasing costs translated into strong EBITDA growth. Adjusted EBITDA from continuing operations increased 20 percent to $320.9 million from $267.4 million last year, and on a per adjusted claim basis set a record at $2.49, a 21 percent increase over $2.06 in the fourth quarter of 2006.

Full-year 2007 Review - Continuing Operations

Total adjusted claims for 2007 were 507.0 million. Network pharmacy claims processed were 379.9 million, home delivery prescriptions were 40.8 million, and SAAS claims were 4.7 million. Generic utilization increased to 61.8 percent from 57.6 percent last year. Gross profit for 2007 increased 20 percent to $1,766.6 million, from $1,476.2 million in 2006, while gross profit per adjusted claim increased 23 percent to $3.48 from $2.84 last year.

The following table provides a reconciliation of reported operating income to adjusted operating income for the PBM and SAAS segments:



                                            Calculation of Adjusted
                                               Operating Income
                                                  Year Ended
                                               December 31, 2007

                                           PBM      SAAS  Consolidated
                                        ------------------------------

 Operating income as reported           $1,037.5  $   23.5   $1,061.0
 Non-recurring legal expenses                6.0        --        6.0
 Non-recurring inventory charges in
  specialty distribution, the majority
  pertained to a write-off of
  flu-related inventory due to the
  mild flu season                             --       9.1        9.1
 Q1 settlement of contractual issue
  with supply chain vendor                  (9.0)       --       (9.0)
 Q3 and Q4 non-recurring items,
  majority of which pertained to bad
  debt charge in specialty distribution
  line of business                            --      21.5       21.5
                                        ------------------------------
 Adjusted operating income              $1,034.5  $   54.1   $1,088.6
                                        ==============================

Adjusted operating income increased 32 percent to $1,088.6 million from $825.8 million last year. Adjusted EBITDA from continuing operations increased 28 percent to $1,186.1 million from $925.6 million last year, and on a per adjusted claim basis, was $2.34, a 31 percent increase over 2006.

Discontinued Operations

The Company reported a net loss from discontinued operations of $27.6 million, or $0.11 per diluted share in the fourth quarter. Excluding non-recurring impairment and restructuring costs, the adjusted loss was $3.7 million or $0.01 per diluted share. For the year, the net loss from discontinued operations was $32.7 million, or $0.12 per diluted share. Excluding the non-recurring impairment and restructuring costs, the adjusted loss was $8.8 million, or $0.03 per diluted share. For additional information, see Table 3 below, or the Annual Report on Form 10-K for the year ended December 31, 2007 filed with the SEC on February 21, 2008.

2008 Earnings Guidance

"The decision to sell the infusion business will allow us to focus on improving the quality and affordability of specialty drug therapy for clients and patients," added Paz. "Our expanded specialty offering has helped us secure more customers in our PBM segment, thereby contributing to the strong results we have enjoyed there. We are well-positioned in the specialty marketplace and will continue to innovate and execute to meet the needs of the marketplace."

As a result of strong underlying trends, the Company believes its 2008 earnings per diluted share from continuing operations will be in a range of $2.92 to $3.00. Lower drug purchasing costs, greater generic utilization, and lower interest costs contributed approximately equally to this increased guidance. The midpoint of this guidance range reflects growth of 24.4 percent over the 2007 adjusted diluted earnings per share from continuing operations of $2.38. Cash flow from operations is expected to be in a range of $875 to $975 million.

Express Scripts, Inc. is one of the largest PBM companies in North America, providing PBM services to over 50 million members through thousands of client groups, including managed-care organizations, insurance carriers, employers, third-party administrators, public sector, workers compensation, and union-sponsored benefit plans.

Express Scripts provides integrated PBM services, including network-pharmacy claims processing, home delivery services, benefit-design consultation, drug-utilization review, formulary management, disease management, and medical- and drug-data analysis services. The Company also distributes a full range of biopharmaceutical products directly to patients or their physicians, and provides extensive cost-management and patient-care services.

Express Scripts is headquartered in St. Louis, Missouri. More information can be found at http://www.express-scripts.com, which includes expanded investor information and resources.

SAFE HARBOR STATEMENT

This press release contains forward-looking statements, including, but not limited to, statements related to the Company's plans, objectives, expectations (financial and otherwise) or intentions. Actual results may differ significantly from those projected or suggested in any forward-looking statements. Factors that may impact these forward-looking statements include but are not limited to:



 * results in regulatory matters, the adoption of new legislation or
   regulations (including increased costs associated with compliance
   with new laws and regulations), more aggressive enforcement of
   existing legislation or regulations, or a change in the
   interpretation of existing legislation or regulations

 * costs and uncertainties of adverse results in litigation, including
   a number of pending class action cases that challenge certain of
   our business practices

 * continued pressure on margins resulting from client demands for
   lower prices, enhanced service offerings and/or higher service
   levels

 * the possible termination of, or unfavorable modification to,
   contracts with key clients or providers, some of which could have a
   material impact on the Company's financial results

 * investigations of certain PBM practices and pharmaceutical pricing,
   marketing and distribution practices currently being conducted by
   various regulatory agencies  and state attorneys general

 * the possible loss, or adverse modification of the terms, of
   contracts with pharmacies in our retail pharmacy network

 * uncertainties associated with our acquisitions, which include
   integration risks and costs, uncertainties associated with client
   retention and repricing of client contracts, and uncertainties
   associated with the operations of acquired businesses

 * changes in industry pricing benchmarks such as average wholesale
   price ("AWP") and average manufacturer price ("AMP"), which could
   have the effect of reducing prices and margins

 * competition in the PBM and specialty pharmacy industries, and our
   ability to consummate contract negotiations with prospective
   clients, as well as competition from new competitors offering
   services that may in whole or in part replace services that we now
   provide to our customers

 * our ability to continue to develop new products, services and
   delivery channels

 * increased compliance risk relating to our contracts with the DoD
   TRICARE Management Activity and various state governments and
   agencies

 * uncertainties regarding the Medicare Part D prescription drug
   benefit, including the financial impact to us to the extent that
   we participate in the program on a risk-bearing basis,
   uncertainties of client or member losses to other providers under
   Medicare Part D, and increased regulatory risk

 * our ability to maintain growth rates, or to control operating or
   capital costs

 * the possible loss, or adverse modification of the terms, of
   relationships with pharmaceutical manufacturers, or changes in
   pricing, discount or other practices of pharmaceutical
   manufacturers or interruption of the supply of any pharmaceutical
   products

 * uncertainties associated with U.S. Centers for Medicare &
   Medicaid's ("CMS") implementation of the Medicare Part B
   Competitive Acquisition Program ("CAP"), including the potential
   loss of clients/revenues to providers choosing to participate in
   the CAP

 * the use and protection of the intellectual property we use in our
   business

 * our leverage and debt service obligations, including the effect of
   certain covenants in our borrowing agreements

 * general developments in the health care industry, including the
   impact of increases in health care costs, changes in drug
   utilization and cost patterns and introductions of new drugs

 * increase in credit risk relative to our clients due to adverse
   economic trends or other factors

 * our ability to attract and retain qualified employees

 * other risks described from time to time in our filings with the SEC

We do not undertake any obligation to release publicly any revisions to such forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.



                       EXPRESS SCRIPTS, INC.
          Unaudited Consolidated Statement of Operations

                            Three months ended    Twelve months ended
                               December 31,          December 31,
                           --------------------- ---------------------
 (in millions, except
  per share data)             2007       2006       2007       2006
                           --------------------- ---------------------

 Revenues (1)              $ 4,694.0  $ 4,500.4  $18,273.6  $17,554.0
 Cost of revenues (1)        4,229.0    4,090.7   16,507.0   16,077.8
                           ---------- ---------- ---------- ----------
  Gross profit                 465.0      409.7    1,766.6    1,476.2
 Selling, general and
  administrative               185.4      167.3      705.6      650.4
                           ---------- ---------- ---------- ----------
 Operating income              279.6      242.4    1,061.0      825.8
                           ---------- ---------- ---------- ----------
 Other (expense) income :
  Non-operating charges, net      --         --     (18.6)         --
  Undistributed loss from
   joint venture                (0.2)      (0.4)      (1.3)      (1.6)
  Interest income                4.1        2.4       12.2       13.7
  Interest expense             (29.3)     (25.1)    (108.4)     (95.7)
                           ---------- ---------- ---------- ----------
                               (25.4)     (23.1)    (116.1)     (83.6)
                           ---------- ---------- ---------- ----------
 Income before income taxes    254.2      219.3      944.9      742.2
 Provision for income taxes     88.1       72.1      344.4      266.8
                           ---------- ---------- ---------- ----------
 Net income from
  continuing operations        166.1      147.2      600.5      475.4
 Net (loss) income from
  discontinued operations,
  net of tax                   (27.6)        --      (32.7)      (1.0)
                           ---------- ---------- ---------- ----------
 Net income                $   138.5  $   147.2  $   567.8  $   474.4
                           ========== ========== ========== ==========

 Weighted average number
  of common shares
  outstanding during
  the period
  - Basic:                     252.3      271.0      260.4      279.6
  - Diluted:                   256.0      274.8      264.0      284.0


 Basic earnings (loss)
  per share:

  Continuing operations    $    0.66  $    0.54  $    2.31  $    1.70
  Discontinued operations      (0.11)        --      (0.13)        --
                           ---------- ---------- ---------- ----------
  Net earnings             $    0.55  $    0.54  $    2.18  $    1.70
                           ========== ========== ========== ==========


 Diluted earnings
  (loss) per share
  Continuing operations    $    0.65  $    0.54  $    2.27  $    1.67
  Discontinued operations      (0.11)        --      (0.12)        --
                           ---------- ---------- ---------- ----------
  Net earnings             $    0.54  $    0.54  $    2.15  $    1.67
                           ========== ========== ========== ==========

(1) Excludes estimated retail pharmacy co-payments of $904.8 and
    $966.0 for the three months ended December 31, 2007 and 2006,
    respectively, and $3,746.3 and $4,175.3 for the twelve months ended
    December 31, 2007 and 2006, respectively.These are amounts we
    instructed retail pharmacies to collect from members.We have no
    information regarding actual co-payments collected.



                          EXPRESS SCRIPTS, INC.
                  Unaudited Consolidated Balance Sheet

                                                  Dec. 31,   Dec. 31,
 (in millions, except share data)                   2007       2006
                                                 ---------- ----------
 Assets
  Current assets:
   Cash and cash equivalents                     $   434.7  $   131.0
   Restricted cash and investments                     2.2         --
   Receivables, net                                1,184.6    1,292.8
   Inventories                                       166.1      191.4
   Deferred taxes                                    121.1       90.5
   Prepaid expenses and other current assets          18.7       18.8
   Current assets of discontinued operations          40.4       47.6
                                                 ---------- ----------
     Total current assets                          1,967.8    1,772.1
 Property and equipment, net                         215.5      198.0
 Goodwill                                          2,695.3    2,679.0
 Other intangible assets, net                        342.0      377.9
 Other assets                                         30.2       69.8
 Non-current assets of discontinued operations         5.6       11.3
                                                 ---------- ----------
     Total assets                                $ 5,256.4  $ 5,108.1
                                                 ========== ==========

 Liabilities and Stockholders' Equity
  Current liabilities:
   Claims and rebates payable                    $ 1,258.9  $ 1,275.7
   Accounts payable                                  517.3      576.1
   Accrued expenses                                  432.5      387.8
   Current maturities of long-term debt              260.1      180.1
   Current liabilities of
    discontinued operations                            6.2        9.7
                                                 ---------- ----------
     Total current liabilities                     2,475.0    2,429.4
 Long-term debt                                    1,760.3    1,270.4
 Other liabilities                                   324.7      283.4
                                                 ---------- ----------
     Total liabilities                             4,560.0    3,983.2
                                                 ---------- ----------

 Stockholders' Equity:
   Preferred stock, 5,000,000 shares
    authorized, $0.01 par value per share; and
    no shares issued and outstanding                    --         --
   Common stock, 650,000,000 shares authorized,
    $0.01 par value per share; shares issued:
    318,886,000 and 159,442,000, respectively;
    shares outstanding: 252,371,000 and
    135,650,000, respectively                          3.2        1.6
   Additional paid-in capital                        564.5      495.3
   Accumulated other comprehensive income             20.9       11.9
   Retained earnings                               2,584.9    2,017.3
                                                 ---------- ----------
                                                   3,173.5    2,526.1
   Common stock in treasury at cost,
    66,515,000 and 23,792,000 shares,
    respectively                                  (2,477.1)  (1,401.2)
                                                 ---------- ----------
     Total stockholders' equity                      696.4    1,124.9
                                                 ---------- ----------
     Total liabilities and stockholders' equity  $ 5,256.4  $ 5,108.1
                                                 ========== ==========



                         EXPRESS SCRIPTS, INC.
         Unaudited Condensed Consolidated Statement of Cash Flows

                                                  Twelve months ended
                                                      December 31,
                                                ----------------------
 (in millions)                                     2007        2006
                                                ----------  ----------

 Cash flow from operating activities:

 Net income                                     $   567.8   $   474.4
 Net loss (income) from discontinued operations,
  net of tax                                         32.7         1.0
                                                ----------  ----------
  Net income from continuing operations             600.5       475.4
 Adjustments to reconcile net income to net cash
  provided by operating activities:
   Depreciation and amortization                     97.5        99.8
   Deferred income taxes                              4.1         7.6
   Bad debt expense                                  36.7        13.5
   Employee stock-based compensation expense         31.6        27.6
   Other, net                                         0.5        (0.1)
  Changes in operating assets and liabilities,
   net of changes resulting from acquisitions:
    Receivables                                      71.6        35.7
    Inventories                                      25.3        77.4
    Other current and non-current assets              6.9        44.5
    Claims and rebates payable                      (16.8)     (104.2)
    Other current and non-current liabilities        (9.8)       (3.7)
                                                ----------  ----------
 Net cash provided by operating activities--
  continuing operations                             848.1       673.5
 Net cash used in operating activities--
  discontinued operations                           (20.8)      (14.9)
                                                ----------  ----------
 Net cash flows from operating activities           827.3       658.6
                                                ----------  ----------
 Cash flows from investing activities:

  Purchases of property and equipment               (75.0)      (66.6)
  Acquisitions, net of cash acquired, and
   investment in joint venture                      (14.3)        0.1
  Sale (purchase) of marketable securities           34.2       (31.5)
  Other                                              (0.7)       (2.8)
                                                ----------  ----------
 Net cash used in investing activities--
  continuing operations                             (55.8)     (100.8)
 Net cash used in investing activities--
  discontinued operations                            (2.5)       (0.2)
                                                ----------  ----------
 Net cash used in investing activities              (58.3)     (101.0)
                                                ----------  ----------
 Cash flows from financing activities:
  Proceeds from long-term debt                      800.0          --
  Repayment of long-term debt                      (180.1)     (110.1)
  Repayments of (proceeds from) revolving
   credit line, net                                 (50.0)       50.0
  Tax benefit relating to employee
   stock compensation                                49.4        30.4
  Treasury stock acquired                        (1,140.3)     (906.8)
  Deferred financing fees                            (1.5)       (0.4)
  Net proceeds from employee stock plans             52.8        32.2
                                                ----------  ----------
 Net cash used in financing activities             (469.7)     (904.7)
                                                ----------  ----------
 Effect of foreign currency
  translation adjustment                              4.4         0.2
                                                ----------  ----------
 Net increase (decrease) in cash and
  cash equivalents                                  303.7      (346.9)
 Cash and cash equivalents at
  beginning of period                               131.0       477.9
                                                ----------  ----------
 Cash and cash equivalents at end of period     $   434.7   $   131.0
                                                ==========  ==========

                        EXPRESS SCRIPTS, INC.
                (In millions, except per claim data)
                             Table 1
                   Unaudited Operating Statistics

                     3 months  3 months  3 months  3 months  3 months
                      ended     ended     ended     ended     ended
                   12/31/2007 9/30/2007 6/30/2007 3/31/2007 12/31/2006
                   ---------- --------- --------- --------- ----------
 Revenues
 --------
 PBM                  3,762.4   3,612.4   3,669.3   3,608.9   3,626.3
 SAAS                   931.6     882.6     906.4     900.0     874.1
                     --------- --------- --------- --------- ---------
  Total consolidated
   revenues           4,694.0   4,495.0   4,575.7   4,508.9   4,500.4
                     ========= ========= ========= ========= =========

 Claims Detail
 -------------
 Network (1)             96.9      92.1      94.1      96.8      97.8
 Home delivery           10.3      10.2      10.2      10.0      10.3
                     --------- --------- --------- --------- ---------
  Total PBM claims      107.2     102.3     104.3     106.8     108.1
                     --------- --------- --------- --------- ---------
  Adjusted PBM
   claims (2)           127.8     122.7     124.8     126.8     128.7
                     ========= ========= ========= ========= =========
 SAAS claims (3)          1.2       1.2       1.2       1.2       1.3
                     --------- --------- --------- --------- ---------
  Total adjusted
   claims (4)           129.0     123.9     126.0     128.0     130.0
                     ========= ========= ========= ========= =========

 Per Adjusted Claim
 ------------------
 Adjusted
  Gross profit       $   3.60  $   3.57  $   3.49  $   3.21  $   3.15
 Adjusted EBITDA     $   2.49  $   2.48  $   2.30  $   2.10  $   2.06



       Calculation of Adjusted EBITDA from Continuing Operations
                                Table 2
                            (In millions)
                                                   3 months   12 months
                                                    ended      ended
                                                 12/31/2007 12/31/2007
                                                 ---------- ----------
 EBITDA (5)
                                                   -------------------
                                                       Consolidated
                                                   -------------------
 EBITDA from continuing operations as reported    $   302.8  $1,158.5
 Q1 Settlement of contractual item with supply
  chain vendor                                           --      (9.0)
 Non-recurring inventory charges in specialty
  distribution, the majority
 pertained to a write-off of flu-related inventory
  due to the mild flu season                            9.1       9.1
 Q3 and Q4 non-recurring items, majority of which
  relates to bad debt charges in specialty
  distribution line of business                         3.0      21.5
 Non-recurring legal expenses                           6.0       6.0
                                                  ---------- ---------
 EBITDA from continuing operations, adjusted      $   320.9  $1,186.1
                                                  ========== =========

 The company is providing adjusted EBITDA excluding the impact of
 non-recurring items, in order to compare the underlying financial
 performance to prior periods.


           Unaudited Earnings Excluding Non-recurring Items
                 (In millions, except per share data)
                                Table 3

                                     Three Months Ended
                          December 31, 2007        December 31, 2006
                       ----------------------  ----------------------
                        Non-                    Non-
                     recurring  Net   Diluted recurring  Net  Diluted
                        Item   Income   EPS     Item   Income    EPS
                        ----   ------   ---     ----   ------    ---

 Net income as reported        $138.5  $ 0.54          $147.2  $ 0.54

 Non-recurring charge
  (benefit) to
  continuing operations
  Non recurring legal
   charges             $  6.0                  $   --
  Non-recurring
   inventory charges in
   specialty
   distribution,
   the majority
   pertained
   to a write-off of
   flu-related inventory
   due to the mild
   flu season             9.1                      --
  Non-recurring bad
   debt charge in the
   SAAS segment           3.0                      --
  Tax benefit from
   change in tax rates     --                    (7.3)
                       ------                  ------
    Total
     non-recurring
     charges             18.1                    (7.3)

  Tax benefit of
   non-recurring
   charges               (6.3)                     --
                       ------                  ------
   Net income impact of
    non-recurring
    charges                      11.8    0.04            (7.3)  (0.03)

 Non-recurring charges
  to discontinued
  operations
  Non-recurring
   impairment and
   restructuring
   charges               34.0                      --

  Tax benefit of
   impairment and
   restructuring
   charges              (10.1)                     --
                       ------                  ------
   Net income impact
    of impairment
    and restructuring
    charge                       23.9    0.10              --      -- 
                               --------------          --------------
 Adjusted earnings             $174.2  $ 0.68          $139.9  $ 0.51
                               ==============          ==============



                                      Twelve Months Ended
                          December 31, 2007        December 31, 2006
                       ----------------------  ----------------------
                        Non-                    Non-
                     recurring  Net   Diluted recurring  Net  Diluted
                        Item   Income   EPS     Item   Income    EPS
                        ----   ------   ---     ----   ------    ---

 Net income as reported        $567.8  $ 2.15          $474.4  $ 1.67

 Non-recurring charge
  (benefit) to
  continuing operations
  Non recurring
   legal charges       $  6.0                  $   --
  Non-recurring
   inventory
   charges in specialty
   distribution, the
   majority pertained
   to a write-off of
   flu-related
   inventory due to the
   mild flu season        9.1                      --
  Non-recurring items,
   majority of which
   pertained to bad debt
   charges in specialty
   distribution line
   of business           21.5                      --
  Settlement of
   contractual
   issue with supply
   chain vendor          (9.0)                     --
  Transaction costs for
   terminated proposal
   to acquire Caremark,
   less special dividend
   received on
   Caremark stock and
   gain on sale of
   Caremark stock        18.6                      --
  Tax benefit from
   change in tax rates     --                    (7.3)
                       ------                  ------
   Total non-recurring
    charges              46.2                    (7.3)

  Tax benefit of
  non-recurring charges (16.8)                     --
                       ------                  ------
   Net income impact of
    non-recurring
    charges                      29.4    0.11            (7.3)  (0.02)


 Non-recurring charges
  to discontinued
  operations
  Non-recurring
   impairment
   and restructuring
   charges               34.0                      --

  Tax benefit of
   impairment and
   restructuring 
   charges              (10.1)                     --
                       ------                  ------
   Net income impact of
    impairment and
    restructuring charge         23.9    0.09              --      --
                               --------------          --------------
 Adjusted earnings             $621.1  $ 2.35          $467.1  $ 1.65
                               ==============          ==============



                        3 Months Ended                12 Months Ended
                           12-31-07                        12-31-07
                       --------------                  --------------
 Summary of adjusted     Net   Diluted                 Net    Diluted
  net income from      Income    EPS                  Income    EPS
  continuing           --------------                  --------------
  operations
  Reported net income
   from continuing
   operations          $166.1  $ 0.65                  $600.5  $ 2.27
  Net income impact of
   non-recurring charges 11.8    0.04                    29.4    0.11
                       --------------                  --------------
  Adjusted net income
   from continuing
   operations          $177.9  $ 0.69                  $629.9  $ 2.38
                       --------------                  --------------

 Summary of adjusted
  loss from
  discontinued
  operations
  Reported net (loss)
   from discontinued
   operations          $(27.6) $(0.11)                 $(32.7) $(0.12)
  Impairment and
   restructuring charge,
   net of tax            23.9    0.10                    23.9    0.09
                       --------------                  --------------
   Adjusted loss from
    discontinued
    operations         $ (3.7) $(0.01)                 $ (8.8) $(0.03)
                    -----------------------------------------------------

 The Company is providing diluted earnings per share excluding the
 impact of certain charges in order to compare the underlying
 financial performance to prior periods.


                Return on Invested Capital ("ROIC")
                           Table 4
                        (In millions)
                                                  2007         2006

 Adjusted operating income                     $ 1,088.6    $   825.8
 Income tax                                        396.8        305.0
                                               ----------   ----------
 Net operating profit after tax ("NOPLAT")     $   691.8    $   520.8

 Stockholders' equity                             $696.4    $ 1,124.9
 Interest bearing liabilities                    2,020.4      1,450.5
 Long-term deferred income taxes, net              278.6        257.1
                                               ----------   ----------
 Invested capital                              $ 2,995.4    $ 2,832.5

 Average invested capital                      $ 2,914.0    $ 3,008.1

 ROIC                                               23.7%        17.3%
                                               ----------   ----------

                     EXPRESS SCRIPTS, INC.

         Notes to Unaudited Operating Statistics
                        (in millions)

 (1)  Network claims exclude drug formulary only claims where we only
      administer the clients formulary and approximately 0.5 million
      manual claims per quarter.

 (2)  PBM adjusted claims represent network claims plus mail claims,
      which are multiplied by 3, as mail claims are typically 90 day
      claims and network claims are generally 30 day claims. Adjusted
      claims calculated from the table may differ due to rounding.

 (3) Specialty and Ancillary Services (SAAS) claims represent the
     distribution of pharmaceuticals through Patient Assistance
     Programs and the distribution of pharmaceuticals where we have
     been selected by the pharmaceutical manufacturer as part of a
     limited distribution network. They also represent the
     distribution of specialty drugs through our CuraScript
     subsidiary.

 (4) Total adjusted claims includes PBM adjusted claims plus SAAS
     claims.

 (5) The following is a reconciliation of EBITDA from continuing
     operations to net income from continuing operations and to net
     cash provided by operating activities from continuing operations
     as the Company believes they are the most directly comparable
     measures calculated under Generally Accepted Accounting Principles:

                                 3 months ended      12 months ended
                                   December 31,        December 31,
                               ------------------  ------------------
                                 2007      2006      2007      2006
                               --------  --------  --------  --------
  Net income from continuing
   operations                  $  166.1  $  147.2  $  600.5  $  475.4
    Income taxes                   88.1      72.1     344.4     266.8
    Depreciation and
     amortization *                23.2      25.0      97.5      99.8
    Interest expense, net          25.2      22.7      96.2      82.0
    Undistributed loss from
     joint venture                  0.2       0.4       1.3       1.6
  Non-operating charges, net         --        --      18.6        --
                               --------  --------  --------  --------
  EBITDA from continuing
   operations                     302.8     267.4   1,158.5     925.6
    Current income taxes          (77.3)    (77.1)   (340.3)   (259.2)
    Interest expense less
     amortization                 (24.6)    (22.2)    (94.0)    (80.0)
    Undistributed loss from
     joint venture                 (0.2)     (0.4)     (1.3)     (1.6)
    Non-operating charges, net       --               (18.6)       --
    Other adjustments to
     reconcile net income to net
     cash provided by operating
     activities                   141.6     141.8     143.8      88.7
                               --------  --------  --------  --------
  Net cash provided by
   operating activities from
   continuing operations       $  342.3  $  309.5  $  848.1  $  673.5
                               ========  ========  ========  ========

 EBITDA is earnings before other income (expense), interest, taxes,
 depreciation and amortization, or operating income plus depreciation
 and amortization. EBITDA is presented because it is a widely accepted
 indicator of a company's ability to service indebtedness and is
 frequently used to evaluate a company's performance. EBITDA, however,
 should not be considered as an alternative to net income, as a
 measure of operating performance, as an alternative to cash flow, as
 a measure of liquidity or as a substitute for any other measure
 computed in accordance with accounting principles generally accepted
 in the United States. In addition, our definition and calculation of
 EBITDA may not be comparable to that used by other companies.

  * Includes depreciation and amortization expense of:

    Gross profit                    6.6       8.8      31.7      35.4
    Selling, general
     and administrative            16.6      16.2      65.8      64.4
                                 -------    ------    ------    ------
                                   23.2      25.0      97.5      99.8
                                 =======    ======    ======    ======

 (6) Represents debt as of the balance sheet date divided by EBITDA
     for the twelve months ended.

 (7) Represents EBITDA for the twelve months ended divided by interest
     expense for the twelve months ended.

 (8) Represents Operating Cash Flow for the twelve months ended
     divided by interest expense for the twelve months ended.

 (9) Represents debt divided by the total of debt and
     stockholders equity.


            

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