Express Scripts Reports a 33 Percent Increase in Third Quarter Earnings Per Share




            Company Raises 2008 Earnings Per Share Guidance

               Provides 2009 Earnings Per Share Guidance

ST. LOUIS, Oct. 30, 2008 (GLOBE NEWSWIRE) -- Express Scripts, Inc. (Nasdaq:ESRX) announced third quarter net income from continuing operations of $203.0 million, or $0.81 per diluted share, representing a 33% increase over $0.61 on an adjusted basis for the same quarter last year. The Company reported year to date cash flow from continuing operations of $727.1 million compared to $505.8 million for year to date 2007.

"In the current economic environment, plan sponsors need us more than ever to help lower their pharmacy spend," stated George Paz, president, chief executive officer and chairman. "As our consumer strategy initiative continues to gain traction in the marketplace, we are demonstrating success in driving to lowest net cost, increasing member engagement and enabling better health and value."

Q3 2008 Financial Highlights (comparative data for 2007 is reflected on an adjusted basis - see tables 2 and 3 below)



 * To be consistent with industry practice, retail co-payments are now
   included in revenues and cost of revenues.  All prior periods have
   been adjusted to reflect this change, which only affects revenues
   and cost of revenues, and has no impact on gross profit or net
   income.
 * The Company's industry-leading generic utilization rate increased
   to 66.2% from 62.2% last year.
 * Gross profit increased 18% to $520.4 million from $440.1 million in
   the third quarter of 2007.
 * EBITDA increased 15% to $354.0 million from $307.0 million last
   year and EBITDA per adjusted claim increased 16% to $2.87 from
   $2.48 last year.
 * Net income from continuing operations increased 28% to $203.0
   million from $158.0 million in the third quarter of 2007.
   -- Net income includes a $2.7 million non-recurring state tax
      benefit.

2008 Guidance

The Company now believes its 2008 earnings per diluted share from continuing operations will be in a range of $3.07 to $3.10. Cash flow from continuing operations is expected to be in a range of $1.0 to $1.1 billion.

2009 Guidance

As a result of the expected growth in generic utilization, home delivery and specialty pharmacy management, as well as lower drug purchasing costs, the Company expects its 2009 diluted earnings per share will be in a range of $3.63 to $3.73.

About Express Scripts

Express Scripts, Inc. is one of the largest PBM companies in North America, providing PBM services to thousands of client groups, including managed-care organizations, insurance carriers, employers, third-party administrators, public sector, workers' compensation, and union-sponsored benefit plans.

Express Scripts provides integrated PBM services, including network-pharmacy claims processing, home delivery services, benefit-design consultation, drug-utilization review, formulary management, and medical- and drug-data analysis services. The Company also distributes a full range of biopharmaceutical products directly to patients or their physicians, and provides extensive cost-management and patient-care services.

Express Scripts is headquartered in St. Louis, Missouri. More information can be found at http://www.express-scripts.com, which includes expanded investor information and resources. More information on the Center for Cost-Effective Consumerism can be found at http://www.consumerology.org.

SAFE HARBOR STATEMENT

This press release contains forward-looking statements, including, but not limited to, statements related to the Company's plans, objectives, expectations (financial and otherwise) or intentions. Actual results may differ significantly from those projected or suggested in any forward-looking statements. Factors that may impact these forward-looking statements can be found in the Management's Discussion and Analysis of Financial Condition and Results of Operations in our Form 10-Q on file with the SEC. A copy of this form can be found at the investor relations section of Express Scripts web site at http://www.express-scripts.com

We do not undertake any obligation to release publicly any revisions to such forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.



                        EXPRESS SCRIPTS, INC.
           Unaudited Consolidated Statement of Operations

                             Three months ended     Nine months ended
                                September 30,         September 30,
 (in millions, except per   --------------------  --------------------
  share data)                 2008        2007      2008        2007
                            ---------  ---------  ---------  ---------

 Revenues(1)                $ 5,450.5  $ 5,358.2  $16,472.1  $16,270.7
 Cost of revenues(1)          4,930.1    4,918.1   14,983.0   14,974.3
                            ---------  ---------  ---------  ---------
  Gross profit                  520.4      440.1    1,489.1    1,296.4
 Selling, general and
  administrative                189.7      174.4      547.1      515.1
                            ---------  ---------  ---------  ---------
 Operating income               330.7      265.7      942.0      781.3
 Other income (expense):
  Non-operating (charges),
   net                           (2.0)       0.2       (2.0)     (18.6)
  Undistributed loss from
   joint venture                 --         (0.3)      (0.3)      (1.1)
  Interest income                 2.1        2.7       10.8        8.1
  Interest expense              (15.7)     (31.3)     (56.1)     (79.1)
                            ---------  ---------  ---------  ---------
                                (15.6)     (28.7)     (47.6)     (90.7)
                            ---------  ---------  ---------  ---------
 Income before income taxes     315.1      237.0      894.4      690.6
 Provision for income taxes     112.1       90.3      321.1      256.2
                            ---------  ---------  ---------  ---------
 Net income from continuing
  operations                    203.0      146.7      573.3      434.4
 Net loss from discontinued
  operations, net of tax         (1.1)      (3.8)      (4.0)      (5.1)
                            ---------  ---------  ---------  ---------
 Net income                 $   201.9  $   142.9  $   569.3  $   429.3
                            =========  =========  =========  =========

 Weighted average number of
  common shares outstanding
  during the period:
  Basic:                        247.1      254.2      249.3      263.1
  Diluted:                      250.3      257.3      252.7      266.3

 Basic earnings per share:
  Continuing operations     $    0.82  $    0.57  $    2.30  $    1.65
  Discontinued operations          --      (0.01)     (0.02)     (0.02)
  Net earnings              $    0.82  $    0.56  $    2.28  $    1.63

 Diluted earnings per share:
  Continuing operations     $    0.81  $    0.57  $    2.27  $    1.63
  Discontinued operations          --      (0.01)     (0.02)     (0.02)
  Net earnings              $    0.81  $    0.56  $    2.25  $    1.61

 (1) Includes retail pharmacy co-payments of $733.7 million and $864.4
     million for the three months ended September 30, 2008 and 2007,
     respectively, and $2,445.5 million and $2,694.0 million for the
     nine months ended September 30, 2008 and 2007, respectively.


                        EXPRESS SCRIPTS, INC.
                Unaudited Consolidated Balance Sheet

                                                  Sept. 30,   Dec. 31,
 (in millions, except share data)                   2008        2007
                                                  ---------  ---------
 Assets
 Current assets:
  Cash and cash equivalents                       $   227.1  $   434.7
  Restricted cash and investments                       3.5        2.2
  Receivables, net                                  1,228.3    1,184.6
  Inventories                                         158.6      166.1
  Deferred taxes                                      113.3      121.1
  Prepaid expenses and other current assets            64.2       18.7
  Current assets of discontinued operations             2.0       40.4
                                                  ---------  ---------
   Total current assets                             1,797.0    1,967.8
 Property and equipment, net                          216.9      215.5
 Goodwill                                           2,905.8    2,695.3
 Other intangible assets, net                         342.8      342.0
 Other assets                                          36.8       30.2
 Non-current assets of discontinued operations           --        5.6
                                                  ---------  ---------
   Total assets                                   $ 5,299.3  $ 5,256.4
                                                  =========  =========

 Liabilities and Stockholders' Equity
 Current liabilities:
  Claims and rebates payable                      $ 1,301.4  $ 1,258.9
  Accounts payable                                    541.4      517.3
  Accrued expenses                                    388.3      432.5
  Current maturities of long-term debt                320.1      260.1
  Current liabilities of discontinued operations        1.1        6.2
                                                  ---------  ---------
   Total current liabilities                        2,552.3    2,475.0
  Long-term debt                                    1,520.3    1,760.3
  Other liabilities                                   361.2      324.7
                                                  ---------  ---------
   Total liabilities                                4,433.8    4,560.0
                                                  ---------  ---------

 Stockholders' Equity:
  Preferred stock, 5,000,000 shares authorized,
   $0.01 par value per share; and no shares
   issued and outstanding                                --         --
  Common stock, 1,000,000,000 shares authorized,
   $0.01 par value; shares issued: 318,940,000
   and 318,886,000, respectively; shares
   outstanding: 247,459,000 and 252,371,000,
   respectively                                         3.2        3.2
  Additional paid-in capital                          627.2      564.5
  Accumulated other comprehensive income               16.9       20.9
  Retained earnings                                 3,154.2    2,584.9
                                                  ---------  ---------
                                                    3,801.5    3,173.5
  Common stock in treasury at cost, 71,481,000
   and 66,515,000 shares, respectively             (2,936.0)  (2,477.1)
                                                  ---------  ---------
   Total stockholders' equity                         865.5      696.4
                                                  ---------  ---------
   Total liabilities and stockholders' equity     $ 5,299.3  $ 5,256.4
                                                  =========  =========


                        EXPRESS SCRIPTS, INC.
      Unaudited Condensed Consolidated Statement of Cash Flows

                                                    Nine months ended
                                                      September 30,
                                                  --------------------
 (in millions)                                      2008        2007
                                                  ---------  ---------

 Cash flows from operating activities:
 Net income                                       $   569.3  $   429.3
 Net loss from discontinued operations, net of tax     4.0         5.1
                                                  ---------  ---------
  Net income from continuing operations               573.3      434.4
 Adjustments to reconcile net income to net cash
  provided by operating activities:
  Depreciation and amortization                        72.9       74.3
  Non-cash adjustments to net income                  100.6       45.2
  Changes in operating assets and liabilities:
   Claims and rebates payable                          33.7      (72.0)
   Other net changes in operating assets and
    liabilities                                       (53.4)      23.9
                                                  ---------  ---------
 Net cash provided by operating activities --
  continuing operations                               727.1      505.8
 Net cash provided by (used in) operating
  activities -- discontinued operations                 1.9       (7.5)
                                                  ---------  ---------
 Net cash flows provided by operating activities      729.0      498.3
                                                  ---------  ---------

 Cash flows from investing activities:
  Purchases of property and equipment                 (59.9)     (47.5)
  Acquisition, net of cash                           (246.5)        --
  Short-term investments transferred from cash        (49.3)        --
  Proceeds from sale of businesses                     27.7         --
  Sale of marketable securities                          --       34.2
  Other                                                (0.9)      (0.6)
                                                  ---------  ---------
 Net cash used in investing activities --
  continuing operations                              (328.9)     (13.9)
 Net cash used in investing activities --
  discontinued operations                              --         (2.0)
                                                  ---------  ---------
 Net cash used in investing activities               (328.9)     (15.9)
                                                  ---------  ---------

 Cash flows from financing activities:
  Proceeds from long-term debt                           --      700.0
  Repayment of long-term debt                        (180.1)    (120.1)
  Repayments of revolving credit line, net               --      (50.0)
  Tax benefit relating to employee stock
   compensation                                        39.2       43.7
  Treasury stock acquired                            (494.4)  (1,140.3)
  Net proceeds from employee stock plans               29.2       47.1
  Deferred financing fees                                --       (1.3)
                                                  ---------  ---------
 Net cash used in financing activities               (606.1)    (520.9)
                                                  ---------  ---------

 Effect of foreign currency translation adjustment     (1.6)       3.5
                                                  ---------  ---------

 Net decrease in cash and cash equivalents           (207.6)     (35.0)
 Cash and cash equivalents at beginning of period     434.7      131.0
                                                  ---------  ---------
 Cash and cash equivalents at end of period       $   227.1  $    96.0
                                                  =========  =========


                        EXPRESS SCRIPTS, INC.
         (In millions, except per claim and per share data)

                               Table 1
                   Unaudited Operating Statistics
 ---------------------------------------------------------------------
                 3 Months   3 Months   3 Months   3 Months   3 Months
                   Ended      Ended      Ended     Ended       Ended
                 9/30/2008  6/30/2008  3/31/2008 12/31/2007  9/30/2007
                 ---------  ---------  --------- ----------  ---------
 Revenues
 --------
 PBM               4,492.8    4,590.7    4,558.5    4,622.9    4,476.8
 SAAS                957.7      940.1      932.3      930.5      881.4
                 -----------------------------------------------------
   Total
    consolidated
    revenues       5,450.5    5,530.8    5,490.8    5,553.4    5,358.2
                 =====================================================

 Claims Detail
 -------------
 Network(1)           91.5       96.1       98.2       96.9       92.1
 Home delivery        10.3       10.3       10.1       10.3       10.2
                 ---------  ---------  ---------  ---------  ---------
  Total PBM
   claims            101.8      106.4      108.3      107.2      102.3
                 ---------  ---------  ---------  ---------  ---------
  Adjusted PBM
   claims(2)         122.4      126.9      128.5      127.8      122.7
                 =========  =========  =========  =========  =========
 SAAS claims(3)        1.1        1.1        1.1        1.2        1.2
                 ---------  ---------  ---------  ---------  ---------
  Total adjusted
   claims(4)         123.5      128.0      129.6      129.0      123.9
                 =========  =========  =========  =========  =========

 Per Adjusted
  Claim
 ------------
 Adjusted
  EBITDA(5)      $    2.87  $    2.67  $    2.46  $    2.49  $    2.48
 ---------------------------------------------------------------------

                               Table 2
      Calculation of 2007 Adjusted Operating Income and EBITDA
 ---------------------------------------------------------------------
                                     3 Months Ended September 30, 2007
                                     ---------------------------------
                                          PBM        SAAS      Total
                                     ---------------------------------


 Operating Income, as reported         $   269.9  $   (4.2)  $   265.7
                                     ---------------------------------
  Non-recurring items, majority of
   which relates to bad debt charge
   in specialty distribution line of
   business                                   --       18.5       18.5
                                     ---------------------------------
 Adjusted Operating Income             $   269.9  $    14.3  $   284.2
                                     =================================

 EBITDA, as reported(5)                                      $   288.5
  Non-recurring items, majority of
   which relates to bad debt charge
   in specialty distribution line of
   business                                                       18.5
                                                             ---------
 Adjusted EBITDA                                             $   307.0
                                                             =========

 The Company is providing adjusted operating income and EBITDA
 excluding the impact of non-recurring charges in order to compare the
 underlying financial performance to prior periods.
 ---------------------------------------------------------------------

                               Table 3

    2007 Unaudited Earnings From Continuing Operations Excluding
                         Non-recurring Items
 ---------------------------------------------------------------------
                                                             3 Months
                                                               Ended
                                                             9/30/2007
                                                             ---------

 Reported income before taxes                                $  237.0

  Non-recurring items, majority of which relates to bad debt
   charge in specialty distribution line of business             18.5
  Transaction costs for terminated proposal to acquire
   Caremark, less special dividend received on Caremark and
   gain on the sale of Caremark stock                            (0.2)
                                                             ---------
  Income before tax excluding non-recurring items               255.3

 Provision for income taxes                                      97.3
                                                             ---------

 Adjusted net income from continuing operations              $  158.0
                                                             =========

 Weighted average number of share outstanding during the
  period - diluted                                              257.3
                                                             =========







 Diluted earnings per share excluding non-recurring items    $   0.61

 Diluted earnings per share from continuing operations as
  reported                                                       0.57
                                                             ---------

 Impact of non-recurring items                               $  (0.04)
                                                             =========

 The Company is providing diluted earnings per share excluding the
 impact of certain charges in order to compare the underlying
 financial performance to prior periods.
 ---------------------------------------------------------------------


                        EXPRESS SCRIPTS, INC.

               Notes to Unaudited Operating Statistics
                            (in millions)

 (1) Network claims exclude drug formulary only claims where we only
 administer the clients formulary and approximately 0.5 million manual
 claims per quarter.

 (2) PBM adjusted claims represent network claims plus mail claims,
 which are multiplied by 3, as mail claims are typically 90 day claims
 and network claims are generally 30 day claims. Adjusted claims
 calculated from the table may differ due to rounding.

 (3) Specialty and Ancillary Services (SAAS) claims represent the
 distribution of pharmaceuticals through Patient Assistance Programs
 and the distribution of pharmaceuticals where we have been selected
 by the pharmaceutical manufacturer as part of a limited distribution
 network. They also represent the distribution of specialty drugs
 through our CuraScript subsidiary.

 (4) Total adjusted claims includes PBM adjusted claims plus SAAS
 claims.

 (5) The following is a reconciliation of EBITDA from continuing
 operations to net income from continuing operations and to net cash
 provided by operating activities from continuing operations as the
 Company believes they are the most directly comparable measures
 calculated under Generally Accepted Accounting Principles:

                                  3 months ended      9 months ended
                                   September 30,       September 30,
                                ------------------  ------------------
                                  2008      2007      2008      2007
                                --------  --------  --------  --------
 Net income from continuing
  operations                    $  203.0  $  146.7  $  573.3  $  434.4
  Income taxes                     112.1      90.3     321.1     256.2
  Depreciation and
   amortization*                    23.3      22.8      72.9      74.3
  Interest expense, net             13.6      28.6      45.3      71.0
  Undistributed loss from joint
   venture                            --       0.3       0.3       1.1
  Non-operating charges, net         2.0      (0.2)      2.0      18.6
                                --------  --------  --------  --------
 EBITDA from continuing
  operations                       354.0     288.5   1,014.9     855.6
  Current income taxes             (94.3)    (90.7)   (289.2)   (262.9)
  Interest expense less
   amortization                    (13.1)    (28.0)    (43.5)    (69.4)
  Undistributed loss from joint
   venture                            --      (0.3)     (0.3)     (1.1)
  Non-operating charges, net        (2.0)      0.2      (2.0)    (18.6)
  Other adjustments to reconcile
   net income to net cash
   provided by operating
   activities                       (0.3)     80.8      47.2       2.2
                                --------  --------  --------  --------
  Net cash provided by operating
   activities from continuing
   operations                   $  244.3  $  250.5  $  727.1  $  505.8
                                ========  ========  ========  ========

 EBITDA is earnings before other income (expense), interest, taxes,
 depreciation and amortization, or operating income plus depreciation
 and amortization. EBITDA is presented because it is a widely accepted
 indicator of a company's ability to service indebtedness and is
 frequently used to evaluate a company's performance. EBITDA, however,
 should not be considered as an alternative to net income, as a measure
 of operating performance, as an alternative to cash flow, as a measure
 of liquidity or as a substitute for any other measure computed in
 accordance with accounting principles generally accepted in the United
 States. In addition, our definition and calculation of EBITDA may not
 be comparable to that used by other companies.

 * Includes depreciation and
    amortization expense of:
     Gross profit                    5.7       6.6      20.0      24.4
     Selling, general and
      administrative                17.6      16.2      52.9      49.9
                                --------  --------  --------  --------
                                    23.3      22.8      72.9      74.3
                                ========  ========  ========  ========


            

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