Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 1 October 2014, the interest of Mr Pascal Soriot, a person discharging
managerial responsibilities, in the ordinary shares of AstraZeneca PLC changed
as detailed below.

The change in interest relates to the previously announced award of restricted
shares made in October 2012 in connection with Mr Soriot's appointment as Chief
Executive Officer. The award vests in three tranches over three years.

After sufficient shares were withheld to satisfy certain tax obligations arising
on the vesting, Mr Soriot has become beneficially entitled to and has received
17,985 shares into a personal brokerage account in respect of the second tranche
of the award.

For tax purposes, the fair market value of the shares at vest was 4441.5 pence
per share being the closing price of AstraZeneca ordinary shares on the last
trading day preceding the vesting day.

A C N Kemp
Company Secretary
2 October 2014