Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 15 June 2015, the interest of Mr Marc Dunoyer, a person discharging
managerial responsibilities, in the ordinary shares of AstraZeneca PLC changed
as detailed below.

The change in interest relates to the vesting of a previously announced award of
restricted shares made to Mr Dunoyer in August 2013. The award vests in three
tranches over three years.

After sufficient shares were withheld to satisfy certain tax obligations arising
on the vesting, Mr Dunoyer has become beneficially entitled to and has received
21,980 shares into a personal brokerage account in respect of the second tranche
of the award.

For tax purposes, the fair market value of the shares at vest was 4211 pence per
share being the closing price of AstraZeneca ordinary shares on the last trading
day preceding the vesting day.

A C N Kemp
Company Secretary
16 June 2015