SEATTLE, Jan. 12, 2017 (GLOBE NEWSWIRE) -- Aptevo Therapeutics Inc. (Nasdaq:APVO), a biotechnology company focused on developing novel oncology and hematology therapeutics, today announced that Dr. John Blankenship, a Lead Scientist at Aptevo, presented new data on the Company’s bispecific antibody program based on the ADAPTIR platform technology at the 16th Annual PEPTALK conference in San Diego, January 9-13, 2017.
In a presentation entitled “ADAPTIR™ Platform, a Novel Platform for Development of Immuno-Oncology Therapeutics,” Dr. Blankenship presented new in vivo, in vitro, pharmacokinetic (PK) and stability data highlighting the advantages of using the ADAPTIR platform to develop novel immuno-oncology therapeutics.
“The field of bispecific therapeutics is a rapidly emerging area in biotechnology and parallels the development of monoclonal antibodies many decades ago, but with greater therapeutic promise," said Dr. Jane Gross, Senior Vice President and Chief Scientific Officer for Aptevo. “The ability to engage the immune system to fight cancer and other chronic diseases is a concept that has been heralded for some time, yet recent technological and scientific advances have made the promise of immunotherapy more achievable.
As pioneers in this field, Aptevo has developed the ADAPTIR platform to engage the immune system in a targeted, controlled fashion. Data presented at the conference showed that ADAPTIR molecules offer key advantages over other bispecific formats, derived in part from the flexible and modular nature of the ADAPTIR structure. Potent biological activity can be achieved, while retaining standard manufacturing characteristics. ADAPTIR bispecific molecules utilize a homodimeric format that avoids the potential manufacturing issues associated with heterodimeric bispecific formats. In addition, ADAPTIR bispecific molecules have demonstrated antibody-like serum half-life in rodents (up to 12 days in mice), in the data presented at PEPTALK.”
Data were also presented showing that ADAPTIR molecules have unique properties for redirecting T-cell cytotoxicity (RTCC) compared to other bispecific platforms, including a favorable cytokine release profile. Preclinical studies presented by Dr. Blankenship at PEPTALK and recently published in the Journal of Molecular and Cellular Biology (2016 Mol Cancer Ther; 15(9); 2155–65.) demonstrated the increased potency of ADAPTIR molecules, which displayed target-dependent induction of RTCC at lower concentrations than other bispecific antibody formats. In addition, in these studies, ADAPTIR molecules were shown to induce T-cell proliferation and serial lysis of target-bearing cells, but with lower levels of T-cell dependent cytokines compared to other bispecific formats. If these data are confirmed in clinical studies, it could suggest the potential for enhanced safety and tolerability compared to other immuno-oncology approaches.
Two ADAPTIR molecules are currently undergoing clinical trials, with several more bispecific immunotherapies in preclinical development. The advantages of the ADAPTIR platform provides an opportunity for diverse therapeutic applications in the future.
About Aptevo Therapeutics Inc.
Aptevo Therapeutics Inc. is a biotechnology company focused on novel oncology and hematology therapeutics to meaningfully improve patients’ lives. Our core technology is the ADAPTIR™ modular protein technology platform. Aptevo has four commercial products in the areas of hematology and infectious diseases, as well as various investigational stage product candidates in immuno-oncology.
Safe Harbor Statement
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Source: Aptevo Therapeutics Stacey Jurchison Senior Director, Investor Relations and Corporate Communications 206-859-6628 JurchisonS@apvo.com