SAN DIEGO, March 27, 2017 (GLOBE NEWSWIRE) -- TRACON Pharmaceuticals (NASDAQ:TCON), a clinical stage biopharmaceutical company focused on the development and commercialization of novel targeted therapeutics for cancer, wet age-related macular degeneration and fibrotic diseases, today announced that TRC694 preclinical data will be presented at the upcoming American Association for Cancer Research (AACR) annual meeting to be held April 1-5, 2017, in Washington, D.C.
Lut Janssen and colleagues from Janssen Research & Development will present a poster featuring data from preclinical studies of TRC694. The presentation details are as follows:
| Abstract Number: | 4199 |
| Abstract Title: | Inhibition of NF-kB inducing kinase (NIK) selectively abrogates NIK and TRAF3 mutant multiple myeloma tumor growth |
| Session Category: | Experimental and Molecular Therapeutics |
| Location: | Section 7, Poster Board Number 22 |
| Date: | Tuesday, April 4, 2017 |
| Time: | 1:00pm – 5:00pm EDT |
The poster will be available on the Company’s website.
About TRC694
TRC694 is a novel, potent, orally bioavailable inhibitor of NF-kB inducing kinase (NIK) with the potential to be first-in-class that was discovered by Janssen and licensed by TRACON in September 2016. In pre-clinical studies, TRC694 selectively repressed P52/RelB mediated non-canonical NF-kB gene expression and inhibited NIK and TRAF3 mutant cell line proliferation in vitro and tumor growth in vivo. Genetic alterations leading to stabilization of NIK are found in a subset of B-cell malignancies: multiple myeloma, mantle-cell lymphoma (where it is associated with ibrutinib resistance), diffuse large B-cell lymphoma, Hodgkin’s lymphoma, and chronic lymphocytic leukemia.
About TRACON
TRACON develops targeted therapies for cancer, ophthalmic and fibrotic diseases. The Company’s clinical-stage pipeline includes: TRC105, an endoglin antibody that is being developed for the treatment of multiple cancers; DE-122, the ophthalmic formulation of TRC105 that is being developed in wet AMD through a collaboration with Santen Pharmaceutical Company Ltd.; and TRC102, a small molecule that is being developed for the treatment of lung cancer and glioblastoma. To learn more about TRACON and its product candidates, visit TRACON's website at www.traconpharma.com.