Renin Alliance of Actelion and Merck & Co., Inc. Achieves Second Milestone

Actelion Receives USD 5M Following Selection of First Compound to Enter Full Pre-Clinical Development


ALLSCHWIL, Switzerland, March 15, 2005 (PRIMEZONE) -- Actelion Ltd (SWX:ATLN) (Other OTC:ALIOF) announced today that the renin alliance with Merck & Co., Inc., (NYSE:MRK) has achieved its second milestone with the selection of the first compound for full pre-clinical development, triggering a milestone payment by Merck to Actelion of USD 5 million.

Actelion and Merck formed an exclusive worldwide alliance in December 2003 to discover, develop and market new classes of renin inhibitors for patients suffering from cardio-renal diseases.

Merck Actelion global renin alliance organization

Through a joint committee, the parties are collaborating on the development of products. Research and development funding initially will be the responsibility of Actelion. The two companies will jointly fund Phase II development, with Merck responsible for funding all Phase III and outcome studies. Merck will lead and fund commercialization. Actelion retains a worldwide option to co-promote any product resulting from this alliance as a paid-for sales force.

Upon signing, Actelion received USD 10 million. Actelion is also eligible to receive significant research, development and approval milestone payments of up to USD 262 million for the successful commercialization of the first collaboration product. A first milestone of USD 15 was achieved in March 2004 with the completion of the technology transfer, which provided Merck with unrestricted access to Actelion's multiple renin inhibitor classes.

Actelion will also be eligible to receive certain milestone payments for the successful commercialization of additional products, and Merck will pay Actelion substantial royalties on the sale of all products resulting from this renin inhibitor alliance.

Scientific background on renin inhibition

Renin plays a key role in the regulation of blood volume, arterial pressure, and cardiac and vascular function by serving as the first component of the renin-angiotensin system. Renin is an enzyme that catalyzes the formation of the hormone angiotensin I, which is transformed by the angiotensin converting enzyme (ACE) to angiotensin II. Angiotensin II acts on specific receptors to increase blood pressure and modulate long-term processes such as arteriosclerosis and remodeling of heart and kidney. Therapeutic manipulation of the renin-angiotensin pathway has become very important in treating hypertension and heart failure.

Renin inhibition is a novel pharmacological approach for the treatment of hypertension, renal failure, and vascular diseases. Actelion has made substantial progress in identifying orally bioavailable and potent renin inhibitors.

Actelion Ltd

Actelion Ltd is a biopharmaceutical company with its corporate headquarters in Allschwil/Basel, Switzerland. Actelion's first drug Tracleer(R), an orally available dual endothelin receptor antagonist, has been approved as a therapy for pulmonary arterial hypertension. Actelion markets Tracleer(R) through its own subsidiaries in key markets worldwide, including the United States (based in South San Francisco), the European Union as well as Canada, Australia and Switzerland. Actelion, founded in late 1997, is a leading player in innovative science related to the endothelium -- the single layer of cells separating every blood vessel from the blood stream. Actelion focuses on the discovery, development and marketing of innovative drugs for significant unmet medical needs. Actelion shares are traded on the SWX Swiss Exchange (ticker symbol: ATLN).



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                                               +1 650 624 6936

 Media Contact           Peter Engel           +41 61 565 66 28
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