Penwest Urges Shareholders to Reject Tang Capital and Perceptive's Wind Down Proposal

Says Choice Between Alternatives is Clear; Cites Company's Board Candidate Qualifications and Criticizes Tang Capital's Track Record in Similar Attempts in Letter to Shareholders


DANBURY, Conn., May 19, 2009 (GLOBE NEWSWIRE) -- Penwest Pharmaceuticals Co. (Nasdaq:PPCO) today sent a letter to its shareholders in connection with the Company's annual meeting to be held on June 10, 2009. Penwest urges shareholders to vote "FOR" Penwest's director nominees on the WHITE proxy card and "AGAINST" the shareholder proposals put forth by Tang Capital Management, L.P. and Perceptive Life Sciences Master Fund Ltd.

The full text of the letter from Paul E. Freiman, Chairman, and Jennifer L. Good, President and Chief Executive Officer, follows:

May 19, 2009


                     VOTE FOR SHAREHOLDER VALUE -
                       OR VOTE TO CALL IT QUITS

Dear Fellow Penwest Shareholder:

Tang Capital Management and Perceptive Life Sciences are engaging in a proxy contest to try to elect some of their in-house personnel to the Penwest Board of Directors at our annual meeting on June 10. They have rejected compromises that could have avoided this costly contest and are instead attempting to gain veto power and effective negative control over important Board decisions that could stalemate Penwest's operations in order to carry out their own agenda for your Company.


                       YOU HAVE A SIMPLE CHOICE

In this proxy contest, you are being asked to make a clear choice between two diametrically opposed views about the Company's strategy and future:


 * The Penwest Board of Directors established a narrowed business
   plan for 2009 intended to both build shareholder value in the
   short term and prepare the Company for long-term growth. Under
   this plan, the Company is focused on maximizing the value of
   Opana(r) ER, advancing the development of A0001 through proof of
   concept, monetizing the value of our proven drug delivery
   technologies and drug formulation expertise, and aggressively
   reducing our costs. We believe these initiatives can build value
   for all shareholders and that it would be a mistake to end them
   prematurely.

   Importantly, we are committed to shutting down any program that we
   determine is not succeeding. For instance, if our findings from
   the A0001 proof of concept trials over the next several months do
   not support further development of the drug, we will promptly
   discontinue this program.

 * The dissidents, on the other hand, want to immediately wind down
   the Company's operations. We believe this strategy ignores the
   value of the assets the Company has developed and the value it can
   create with them in the near term. In addition, the strategy is
   short-sighted, is less practical than the dissidents have led
   shareholders to believe, would take a long time to carry out and
   would adversely affect shareholder value. For example, pursuing it
   could result in our forfeiting approximately $91 million of
   available net operating loss carryforwards and jeopardizing our
   listing on NASDAQ.

  YOUR BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT YOU VOTE "FOR"
 THE ELECTION OF THE COMPANY'S NOMINEES AND "AGAINST" THE DISSIDENTS'
              PROPOSALS ON THE ENCLOSED WHITE PROXY CARD.

We believe that, just as there are clear distinctions between these two strategies, there are sharp differences between the parties who support them. It is important for you to be aware of key facts regarding the proponents of the opposing strategies.


                          TANG CLAIMS TO BE
      LOOKING OUT FOR THE INTERESTS OF PENWEST'S SHAREHOLDERS -
         BUT A CLOSER LOOK AT HIS ACTIONS IN OTHER COMPANIES
                             IS REVEALING

 * The recent fiasco at Vanda Pharmaceuticals graphically
   demonstrates Mr. Tang's poor judgment concerning a company's
   strategy and prospects, and the potential value of a product
   candidate.  After launching a proxy fight against Vanda in
   February to force the immediate wind down of that company's
   operations, Tang Capital suddenly abandoned its campaign earlier
   this month right after Vanda announced that the FDA had granted
   marketing approval of its schizophrenia drug Fanapt -- a product
   whose alleged poor chances for approval were central to Mr. Tang's
   flawed thesis about Vanda's prospects going forward.

 * Mr. Tang has given a misleading account of how events played out
   at Ardea Biosciences, another company with which he is involved.
   He tries to take credit for the "swift and effective" wind down of
   Ardea's operations as evidence of the feasibility of his proposed
   strategy for Penwest.  But the reality is that Ardea had
   $50 million of cash that was never distributed to shareholders as
   he proposes that Penwest do.  Instead, Ardea used its cash to
   acquire new assets, rebuilt its business and prospered.  An
   inconvenient truth for Mr. Tang, the Ardea case shows the
   potential value to shareholders of investing in promising assets --
   rather than prematurely halting operations.  If Mr. Tang had
   implemented at Ardea the strategy he is pursuing with Penwest,
   Ardea shareholders would never have received that value.

    THE PENWEST BOARD HAS THE RIGHT SKILLS, EXPERTISE AND FOCUS TO
                        BUILD SHAREHOLDER VALUE

Penwest's Board is highly qualified and fully committed to protecting the interests of all shareholders:


 * Since 2006, we have been building a Board composed of experienced,
   highly-qualified directors who have been successful leading
   companies in the biotechnology and pharmaceutical industries and
   who bring valuable skills to our Company.  After this election,
   assuming our nominees are elected, only three of our directors
   will have served on the Board for more than three years.  If our
   nominees are elected, a valuable combination of scientific,
   regulatory, medical, commercial, strategic and financial expertise
   will be represented on the Board.

 * W. James O'Shea, our nominee who is a current director, is an
   experienced pharmaceutical executive and a highly-respected,
   independent industry expert with a strong track record in hands-on
   executive and operating roles at public companies.  During his
   tenure as President and Chief Operating Officer, and then as Vice
   Chairman, of Sepracor Inc., a research-based pharmaceutical
   company, from 1999 to 2007, Sepracor's annual revenues grew from
   $22.7 million to $1.2 billion.  This revenue growth was led by the
   re-launch of Xopenex, which generated annual revenues of
   approximately $440 million at their highest level, and the launch
   of Lunesta, which peaked at full-year sales of approximately
   $600 million.  Mr. O'Shea was responsible for the launches and
   commercial oversight of both products.

 * Importantly, as demonstrated by our recommendation that you vote
   to elect as a director Joseph Edelman, a member of the dissident
   slate, the Penwest Board is not opposed to considering alternative
   views.  We believe that this nomination reflects your Company's
   balanced, reasonable approach to ensuring that the dissidents'
   views will be represented in its decision making while not
   affording them the veto power over the Company's operations that
   they are seeking.

 * While the dissidents want you to believe that the Board's recent
   adoption of a limited-duration shareholder rights plan means that
   we are entrenched, the fact is that we put a rights plan back in
   place for 15 months in order to ensure that all Penwest
   shareholders have the opportunity to benefit from our initiatives
   to build shareholder value this year and into 2010.  We believe
   that the limited duration plan will give the Company an
   appropriate amount of time to execute its strategy.  We have
   purposely provided in the rights plan that the plan will expire on
   July 1, 2010, unless shareholders decide to extend it beyond that
   date.

  TANG CAPITAL'S QUESTIONABLE TACTICS IN THIS CONTEST SHOULD CONCERN
                        PENWEST'S SHAREHOLDERS

We believe that Tang Capital's questionable tactics in this proxy contest make its in-house personnel unsuitable candidates for your Board.


 * Tang Capital has twice offered in writing to give the Company's
   directors personally the A0001 asset and business opportunity for
   their own financial benefit without their having to pay the
   Company anything.  Of course, this is not appropriate and not
   something your directors would ever consider.  We would never seek
   to profit personally from a Company asset.

 * Mr. Tang proposed to the Company's CEO that a majority of the
   Board resign, in exchange for severance payments, so that the
   dissidents could immediately gain complete control of the Company.
   We have never had severance payments for departing directors.
   Your Board is committed to doing the job it was elected to do,
   and will not abandon its fiduciary duty.

 * Mr. Tang rejected the offer to discuss a compromise slate of Board
   seats as a compromise to avoid this unnecessary and distracting
   proxy fight -- because he wants as much immediate control as he
   can get.

 * The dissidents have caused your Company to incur significant costs
   resulting from this proxy contest and their related litigation.
   As part of their tactics, they have filed three separate lawsuits
   against the Company (one of which has since been dropped).  The
   demands of defending against this litigation are not only onerous
   for the Board and management but also costly for the Company and
   its shareholders.  Our estimated cost to defend this litigation
   and proxy contest is approximately the same as the cost to run a
   Phase IIa proof of concept trial for A0001, which the dissidents
   are so vigorously trying to stop, claiming that it is a "waste of
   corporate assets."  Isn't this ironic?

We believe that Tang Capital's interests are not aligned with those of many of Penwest's long-term shareholders due to its low cost basis of $1.32 for its Penwest shares and its accumulation of more than 21% of Penwest's outstanding shares within the past five months. Almost immediately after acquiring its shares, Tang Capital filed a Schedule 13D and declared itself an activist.


                       PROTECT YOUR INVESTMENT

We have significantly improved the Company's financial performance, including sharply reducing costs. We are successfully implementing our strategy with focused goals for 2009, and expect to be profitable on a quarterly basis in the fourth quarter this year and for the full year in 2010. Don't let the value of your investment in Penwest be prematurely capped, just when we are about to achieve profitability and are close to better understanding the potential value of the Company's A0001 asset.

PLEASE USE THE WHITE PROXY CARD TO VOTE TODAY - BY TELEPHONE, BY INTERNET OR BY SIGNING, DATING AND RETURNING THE ENCLOSED WHITE PROXY CARD. YOUR BOARD URGES YOU NOT TO SIGN OR RETURN ANY GOLD OR OTHER PROXY CARD SENT TO YOU BY TANG CAPITAL OR PERCEPTIVE.

The contrast between the two strategies is stark, as are the differences in the ways the two parties involved conduct themselves. The choice is yours. Your Board is convinced that we are following the right path for Penwest to build value for all shareholders. We strongly believe that the dissidents' immediate wind down strategy is contrary to the interests of Penwest and its shareholders.


 Sincerely,



 Paul E. Freiman            Jennifer L. Good
 Chairman                   President and Chief Executive Officer

About Penwest Pharmaceuticals

Penwest is a drug development company focused on identifying and developing products that address unmet medical needs, primarily for rare disorders of the nervous system. Penwest is currently developing A0001, a coenzyme Q analog drug candidate for inherited mitochondrial respiratory chain diseases. Penwest is also applying its drug delivery technologies and drug formulation expertise to the formulation of product candidates under licensing collaborations with partners.

Penwest Forward-Looking Statements

The matters discussed herein contain forward-looking statements that involve risks and uncertainties, which may cause the actual results in future periods to be materially different from any future performance suggested herein. For this purpose, any statements contained herein that are not statements of historical fact may be deemed to be forward-looking statements. Without limiting the foregoing, the words, "believes," "anticipates," "plans," "expects," "intends," "potential," "appears," "estimates," "projects," "targets," "may," "could," and similar expressions are intended to identify forward-looking statements. Important factors that could cause results to differ materially include: risks relating to the commercial success of Opana ER, including our reliance on Endo Pharmaceuticals Inc. for the commercial success of Opana ER and risks of generic competition; the need for capital; regulatory risks relating to drugs in development, including the timing and outcome of regulatory submissions and regulatory actions; uncertainty of success of collaborations; the timing of clinical trials; whether the results of clinical trials will warrant further clinical trials, warrant submission of an application for regulatory approval of, or warrant the regulatory approval of, the product that is the subject of the trial; whether the patents and patent applications owned by us will protect the Company's products and technology; actual and potential competition; and other risks as set forth under the caption Risk Factors in Penwest's Annual Report on Form 10-Q filed with the Securities and Exchange Commission on May 11, 2009, which risk factors are incorporated herein by reference.

The forward-looking statements contained in this press release speak only as of the date of the statements made. Penwest disclaims any intention or obligation to update any forward-looking statements, and these statements should not be relied upon as representing the Company's estimates or views as of any date subsequent to the date of this letter.

TIMERx is a registered trademark of Penwest. All other trademarks referenced herein are the property of their respective owners.


                 INFORMATION CONCERNING PARTICIPANTS

Information required to be disclosed with regard to the Company's directors, director nominees, officers and employees who, under the rules of the Securities and Exchange Commission (the "SEC"), are considered to be "participants" in the Company's solicitation of proxies from its stockholders in connection with its 2009 Annual Meeting of Stockholders (the "Annual Meeting") may be found in the Company's Proxy Statement for its 2009 Annual Meeting of Stockholders, as filed with the SEC on May 7, 2009 (the "2009 Proxy Statement").

Security holders may obtain a free copy of the 2009 Proxy Statement and other documents (when available) that the Company files with the SEC at the SEC's website at www.sec.gov. Security holders may also obtain a free copy of these documents by writing the Company at Penwest Pharmaceuticals Co., 39 Old Ridgebury Road, Suite 11, Danbury, CT 08610, attn: Controller, or by telephoning the Company at (877) 736-9378.

We have circulated a WHITE proxy card together with our definitive proxy statement. We urge shareholders to vote FOR our nominees on the WHITE proxy card and not to sign or return a green, gold or other colored proxy card to the Company.



            

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