Cholangiocarcinoma Pipeline Insight: Therapeutic analysis of 70+ pipeline therapies and 70+ pharmaceutical companies 

Cholangiocarcinoma Pipeline is majorly witnessing TAS-120, AG-120, E7090, and E7090 as the most anticipating therapies.


Los Angeles, USA, March 16, 2021 (GLOBE NEWSWIRE) -- Cholangiocarcinoma Pipeline Insight: Therapeutic analysis of 70+ pipeline therapies and 70+ pharmaceutical companies 

Cholangiocarcinoma Pipeline is majorly witnessing TAS-120, AG-120, E7090, and E7090 as the most anticipating therapies.

DelveInsight’s ‘Cholangiocarcinoma (CCA) Pipeline Insights’ report provides a comprehensive portfolio of pipeline therapies and key pharmaceutical companies actively engaged in the domain. 

The report lays down complete information on the drug profiles, stages of their clinical development, MoA, RoA, molecule type, and drug delivery platform.  Besides, the report proffers a view on 

Some of the crucial takeaways from the Cholangiocarcinoma Pipeline report:

  • The Cholangiocarcinoma pipeline comprises TT-00420 (TransThera Biosciences), and STP-705 (Sirnaomics) in Phase I clinical stage of development, while CX-4945 (Senhwa Biosciences) and MIV-818 (Medivir) are in Phase I/II stage. 
  • In mid-stage of development of Cholangiocarcinoma pipeline therapies comprises HMPL-453 (Hutchison Medipharma) and E7090 (Eisai) are in Phase II with Bintrafusp alfa (EMD Serono) in Phase II/III stage of clinical trials. 
  • AG-120 (Agios Pharmaceuticals) and TAS-120 (Taiho Oncology) are in the late-stage of Cholangiocarcinoma pipeline.
  • Key companies dedicated to advance the Cholangiocarcinoma drug pipeline are: Medivir, Hutchison Medipharma, Agios Pharmaceuticals, TransThera Biosciences, Senhwa Biosciences, Eisai, EMD Serono, Taiho Oncology, Sirnaomics, RedHill Biopharma, MacroGenics, Chia Tai Tianqing Pharmaceutical Group, Sirtex Medical,   Delcath Systems Inc. Innovent Biologics, PCI Biotech AS, Basilea Pharmaceutica, QED Therapeutics, Bristol-Myers Squibb, AstraZeneca, Eli Lilly and Company, Toray Industries, Bold Therapeutics and several others.  
  • On March 1, 2021, Agios Pharmaceuticals submitted a Supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) for Ivosidenib tablets (AG-120) as a potential treatment for patients with previously treated isocitrate dehydrogenase 1 (IDH1) mutated cholangiocarcinoma.
  • In May 2020, Bold Therapeutics entered into an option agreement with an Hana Pharm Co Ltd for exclusive rights to BOLD 100 in South Korea. Under the terms of the agreement, Bold Therapeutics and Hana Pharm will collaborate for a planned phase Ib/IIa adaptive trial in gastric, pancreatic, colorectal and bile duct (cholangiocarinoma) cancer.

Visit for holistic view @ Cholangiocarcinoma Drug Pipeline  

Cholangiocarcinoma is cancer that arises from the cells lining the bile duct, a drainage system for the bile that is produced by the liver. This condition, also known as bile duct cancer, is an uncommon form of cancer that occurs mostly in people older than age 50, though it can occur at any age. Cholangiocarcinomas are part of the family of tumors known as adenocarcinomas, which originate in glandular tissue. Less commonly, they’re squamous cell carcinomas, which develop in the squamous cells that line the digestive tract.

Cholangiocarcinoma Drug Profiles 

HMPL-453: Hutchison Medipharma Limited 

HMPL‑453 is a novel, highly selective, and potent small-molecule inhibitor that targets FGFR 1, 2, and 3. Hutchison China MediTech Limited (“Chi-Med”) is investigating the therapy in the Phase II stage of development in patients with advanced intrahepatic cholangiocarcinoma (“IHCC”) (NCT04353375).

Cholangiocarcinoma Therapeutic Assessment 

By Product Type

  • Mono
  • Combination

By Stage

  • Discovery 
  • Pre-clinical
  • Phase I
  • Phase II
  • Phase III
  • Pre-registration

By Route of Administration

  • Oral
  • Intravenous
  • Inhalation
  • Subcutaneous
  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Parenteral
  • Topical

By Molecule Type

  • Gene therapy
  • Small molecules
  • Stem cell therapy
  • Gene therapies
  • Vaccines
  • Polymers
  • Peptides
  • Monoclonal antibodies

By Mechanism of Action

  • Immunomodulatory
  •  DNA synthesis inhibitors
  • Type 1, 2, 3 fibroblast growth factor receptor antagonist 
  • Isocitrate dehydrogenase 1 inhibitors
  • Sphingosine kinase inhibitors
  • Casein kinase II inhibitors
  • Type 1, 2, 3, 4 fibroblast growth factor receptor antagonists
  • Cyclo-oxygenase 2 inhibitors; RNA interference; Transforming growth factor beta1 inhibitors
  • Antibody-dependent cell cytotoxicity; Cytotoxic T lymphocyte stimulants; Natural killer cell stimulants; Programmed cell death-1 ligand-1 inhibitors; Transforming growth factor beta inhibitors
  • Aurora kinase A inhibitors; Aurora kinase B inhibitors; Receptor protein-tyrosine kinase antagonists 

By Targets

  • Protease
  • Immunomodulatory
  • Multiple kinases

By Stage and Molecule Type
By Stage and Route of Administration
By Stage and Product Type

Key Pipeline Therapies

Pipeline Therapy CompanyPhase MoARoA
MIV-818MedivirI/IIDNA synthesis inhibitorsOral
HMPL-453Hutchison MedipharmaIIType 1 fibroblast growth factor receptor antagonistsOral
BOLD-100Bold TherapeuticsIApoptosis stimulants; DNA inhibitors; Molecular chaperone GRP78 protein inhibitorsIntravenous
TT-00420TransThera BiosciencesIAurora kinase A inhibitors; Aurora kinase B inhibitors; Receptor protein-tyrosine kinase antagonistsOral
CX-4945Senhwa BiosciencesI/IICasein kinase II inhibitorsIntravenous
E7090 EisaiIIType 1, 2, 3 fibroblast growth factor receptor antagonistOral
Bintrafusp alfaEMD SeronoII/IIIAntibody-dependent cell cytotoxicity; Cytotoxic T lymphocyte stimulants; Natural killer cell stimulants; Programmed cell death-1 ligand-1 inhibitors; Transforming growth factor-beta inhibitorsIntravenous
TAS-120Taiho OncologyIIIType 1, 2, 3, 4 fibroblast growth factor receptor antagonistsOral
STP-705SirnaomicsICyclo-oxygenase 2 inhibitors; RNA interference; Transforming growth factor beta1 inhibitorsIntratumoral
ABC294640RedHill Biopharma IISphingosine kinase inhibitorsOral

Know more about the Cholangiocarcinoma Pipeline Therapies and Emerging Trends 

Scope of the Report

Coverage: Global
Key Players: Medivir, Hutchison Medipharma, Agios Pharmaceuticals, TransThera Biosciences, Senhwa Biosciences, Eisai, EMD Serono, Taiho Oncology, Sirnaomics, RedHill Biopharma, MacroGenics, Chia Tai Tianqing Pharmaceutical Group, Sirtex Medical,   Delcath Systems Inc. Innovent Biologics, PCI Biotech AS, Basilea Pharmaceutica, QED Therapeutics, Bristol-Myers Squibb, AstraZeneca, Eli Lilly and Company, Toray Industries, Bold Therapeutics, and others.
Key Cholangiocarcinoma Pipeline Therapies: MIV-818, HMPL-453, BOLD-100, TT-00420, CX-4945, E7090, Bintrafusp alfa, TAS-120, STP-705, ABC294640, among several others.
Key Questions Answered 

  • What are the current options for Cholangiocarcinoma treatment?
  • How many companies are developing therapies for the treatment of CCA? 
  • What are the principal therapies developed by these companies in the industry?
  • How many Cholangiocarcinoma emerging therapies are in the early-stage, mid-stage, and late stage of development for the treatment of CCA?
  • Out of total pipeline products, how many therapies are given as a monotherapy and in combination with other therapies? 
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, and major licensing activities that will impact the CCA market? 
  • Which are the dormant and discontinued products and the reasons for the same?
  • What is the unmet need for current therapies for the treatment of CCA?  
  • What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing CCA therapies? 
  • What are the key designations that have been granted for the emerging therapies for Cholangiocarcinoma (CCA)? 

Got queries? Get answers @ CCA Emerging Therapies 

Table of Contents 

1Introduction
2Executive Summary
3Cholangiocarcinoma Overview
4CCA Pipeline Pipeline Therapeutics
5Cholangiocarcinoma Pipeline Therapeutic Assessment
6CCA – DelveInsight’s Analytical Perspective
7In-depth Commercial Cholangiocarcinoma Pipeline Assessment
8Cholangiocarcinoma Collaboration Deals
9Late Stage CCA Pipeline Products (Phase III and Preregistration)
10Mid-Stage Cholangiocarcinoma Pipeline Products (Phase II)
11Early-Stage Cholangiocarcinoma Pipeline Products (Phase I)
12Pre-clinical and Discovery Stage CCA Pipeline Products
13Inactive CCA Pipeline Products
14 CCA Inactive Products
15Cholangiocarcinoma Discontinued Products
16Cholangiocarcinoma Dormant Products
17Cholangiocarcinoma Key Companies
18CCA Key Product Profiles
20Cholangiocarcinoma Unmet Needs
21CCA Market Drivers and Barriers
22CCA Future Perspectives
23Cholangiocarcinoma Analyst Views
24Cholangiocarcinoma Pipeline Report Methodology
25Appendix

Reach out for a live demo of the report @ Cholangiocarcinoma Emerging Therapies 

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