Announcement Report of transactions with shares and related securities of NeuroSearch by persons discharging managerial responsibilities and person/companies closely associated with these Pursuant to section 28a of the Danish Act on Securities Trading, NeuroSearch A/S (NEUR.CO) shall make public transactions with shares and related securities of NeuroSearch A/S by persons discharging managerial responsibilities and persons/companies closely associated with these. Name: Lars Siim Madsen Reason: Member of the Board Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 1,171 Market value (DKK): 295,092 Name: Torben Skov Reason: Member of the Board Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 585 Market value (DKK): 147,420 Name: Flemming Pedersen Reason: CEO Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 5,782 Market value (DKK): 1,457,064 Name: Jørgen Drejer Reason: Executive Vice President, Director of Drug Discovery Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 4,098 Market value (DKK): 1,032,696 Name: Finn Eggert Sørensen Reason: Executive Vice President, CBO Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 7,025 Market value (DKK): 1,770,300 Name: Frank Wätjen Reason: Executive Vice President, Director of Drug Development Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 4,098 Market value (DKK): 1,032,696 Name: Palle Christophersen Reason: Vice President, Director of In Vitro Pharmacology Issuer and ID code / ISIN: NeuroSearch: A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 2,342 Market value (DKK): 590,184 Name: Anita Milland Reason: Vice President, CFO Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 878 Market value (DKK): 221,256 Name: Naheed Mirza Reason: Vice President, Director of In Vivo Pharmacology Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 2,342 Market value (DKK): 590,184 Name: Jette Møllmann Reason: Vice President, Director of Legal Department Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 3,513 Market value (DKK): 885,276 Name: Dorte Filtenborg Olesen Reason: Vice President, Director of CMC Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 585 Market value (DKK): 147,420 Name: Dan Peters Reason: Vice President, Director of Medicinal Chemistry Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 2,927 Market value (DKK): 737,604 Name: Daniel Brunicardi Timmermann Reason: Vice President, Director of Ion Channel Therapeutics Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 1,171 Market value (DKK): 295,092 Name: Thomas Varming Reason: Vice President, Head of R&D Administration Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 2,342 Market value (DKK): 590,184 Name: Peder Velling Reason: Vice President, Head of Patent Department Issuer and ID code / ISIN: NeuroSearch A/S / DK0010224666 Transaction: Sale of shares Trading date: 12 March 2007 Market: Copenhagen Stock Exchange Number (pcs): 2,342 Market value (DKK): 590,184 Asger Aamund Chairman of the Board Contact person: Anita Milland, Vice President, CFO Telephone: +45 4460 8274 or +45 2016 3432 NeuroSearch is a Scandinavian biopharmaceutical company listed on the Copenhagen Stock Exchange (NEUR). Our core business covers the development of novel drugs, based on a broad and well-established drug discovery platform focusing on ion channels and transporters. A substantial part of the company's activities are partner financed through a broad alliance with GlaxoSmithKline (GSK) and collaborations with among others Abbott and Astellas. Eight drug programmes are in clinical development: ACR16 for the treatment of Huntington's disease (under preparation for Phase III), tesofensine for the treatment of obesity/type 2 diabetes (Phase II), NS2359 for the treatment of depression (Phase II) and ADHD (Phase II) in partnership with GSK, NS1209 for the treatment of epilepsy and pain (Phase II), ABT-894 for the treatment of ADHD (Phase II) and neuropathic pain (Phase I) in partnership with Abbott, ACR16 for the treatment of schizophrenia (Phase I) in partnership with Astellas, and ACR325 for the treatment of psychoses such as bipolar disorder (Phase I). In addition, NeuroSearch has a broad portfolio of preclinical drug candidates and has equity interests in several biotech companies.
Report of transactions with shares and related securities of NeuroSearch by persons discharging managerial responsibilities and person/companies closely associated with these
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